Please visit for 12th Annual Frye Halloran Symposium on April 16, 2013.



Massachusetts General Hospital

APRIL 16, 2013

        The Frye - Halloran Symposium is an annual event that aims to facilitate the transition of promising innovations from the laboratory to the care of the patient.  Noteworthy past symposia have included the introduction of micro dialysis for real-time in situ measurement of activated drugs, the identification of novel MRI signal changes as markers of the effect of angiogenesis inhibitors, the development of therapies based upon viral vectors and cell-based immunizations, and racial diversity in glioma patient populations. The 2012 Symposium led to the identification of IDH1 mutations as biomarkers for the diagnosis of brain tumors.

        The 2013 symposium, taking place at the Massachusetts General Hospital on April 16, brings together international exosome experts:
(1) Jan Lötvall MD PhD - Introduction of ISEV
(2) Johan Skog PhD - Characterization and Speciation and Analytics of Exosomes: The Latest Development in Translational Technologies
Alain Brisson PhD - Cryo-Electron Microscopy and Specific Gold Labeling of Plasmatic Microvesicles
Xandra Breakefield PhD - TBD
Héctor Peinado PhD - Exosomes and the Nervous System
Molecular Biology, Diagnosis and Therapeutic Implications
Stefano Pluchino MD PhD - Inflammation-reactive exosome signaling pathways and therapeutic plasticity of neural stem cell    transplants (8)Steve Gould PhD - Therapeutic Implications (9) Bruce Chabner MD - Exosomes that Fill the Unmet Need in Clinical Cancer Trials

            The ISEV (International Society of Extracellular Vesicles) meeting will address the molecular revolution by which cell derived microparticles can provide diagnosis of gliomas, can be used to biomark for response and prognosis and offer the possibility of novel therapeutics.  With the identification of glioma specific recurrent mutations in the last 5 years, we are now on the cusp of translating these molecular discoveries into meaningful clinical strategies for patient care. Exosome studies will play a major role in these advances.  This symposium will provide clinicians with a working understanding of this emerging field, set the stage for upcoming clinical trials and opportunities for collaboration. Most importantly observations linking exosomes to the nervous system can be extrapolated to a wider range of infectious diseases and immunologic control mechanisms.

               The one day Frye Halloran Educational Symposium will be divided into 3 sessions:      

               Session 1 - Definitions and Basic Understanding of Exosomes and 
                                   Extracellular MicroVesicles
               Session 2 - Application of Analytics to the Identification of Exosomes in Biofluids
               Session 3 - Clinical Diagnostic and Therapeutic Studies of Exosomes in the Nervous System
    We envision the meeting to be of interest to clinicians and laboratory scientists in the fields of neurology, neuro-oncology, neurosurgery, neuropathology, radiation oncology, neuroradiology, nursing and other specialties involved in the research, diagnosis, care and treatment of patients with neurological conditions. 
    Registration is required. To register, please visit Thank you.